We had to rescind our offer right before the inspection period ended, but it was the sellers' fault, not the house's fault. There were some expensive things that came up in the inspection, but not shocking or deal breakers considering the house was built in 1890, but we wanted to renegotiate on the price. But the wife was unreachable on vacation as was their idiot nephew who was their realtor. He said he didn't realize both husband and wife had to sign the paperwork. (Actually he admitted months later that he lied to our agent, but he didn't know what else to do when he realized she'd gone on vacation.)
We had to rescind so that we wouldn't be stuck with it and lose our earnest money. Weeks later we were finally able to get them to renegotiate with us, but I think their divorce was the biggest factor in our problems. Hopefully that isn't something you will have to deal with. GL!